STAT+: Scientists debut map of basal ganglia, a key brain region involved in an array of diseases
A massive scientific collaboration meant to unravel the mysteries of the human brain has produced the most detailed map yet of the basal ganglia, a region closely associated with a wide array of psychiatric and neurologic disorders.
Key points
- Authors working in mouse models of Parkinson’s disease showed that a gene therapy designed to work in a subset of basal ganglia cells was as effective as a blanket approach; it was also safer.
- In the process scientists discovered a new type of neuron that appears to play a role in schizophrenia.
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Demonstrating the value of the work, the scientists produced preliminary evidence that they can use their more detailed understanding of brain cell types to deliver therapies with increased precision.
Additional details
- They also identified cell types linked to depression, bipolar disorder, and post-traumatic stress disorder.
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