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STAT+: Ionis Pharmaceuticals shares plummet after slow rollout of biotech’s triglyceride-lowering drug

Ionis Pharmaceuticals lost more than $1 billion in market value on Monday after the company slashed sales projections for a triglyceride-lowering drug the biotech and Wall Street analysts believe is a potential blockbuster.

✦ Extractive summary — built from the sources' own reporting•From 1 source•1 min read•Updated November 10, 2026, 12:50 AM UTC
Key points
  • Third quarter sales came in at $9 million, well below Wall Street consensus expectations of $21 million during the quarter.
  • Continue to STAT+ to read the full story….

The firm announced that it expects the drug, Tryngolza, to bring in $50 million in sales by the end of this year, compared to Ionis’ previous forecast of $100 to $110 million.

Shares that traded at more than $39 when the market opened within hours sank below $28, a drop of around 25%.

How this summary was made: extractive summary — built from the sources' own reporting. It is drawn only from the reporting of the sources listed below — read the originals for full detail. How we summarize →

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