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Fantasy Football Start 'Em, Sit 'Em: Week 10 lineup advice, best matchups, DFS picks

Welcome to Week 10 of another NFL season of fantasy football start/sit lineup advice from The Sporting News.

✦ Extractive summary — built from the sources' own reporting•From 1 source•1 min read•Updated November 11, 2026, 3:05 PM UTC
Key points
  • Keep scrolling for tips on how to deploy the best fantasy football lineup for your league opener.
  • DFS QB Week 10 pick Brock Purdy, 49ers (at DAL, $7,000 on DraftKings, $8,200 on FanDuel): Purdy should need to keep on passing on the road to make sure the Cowboys don't catch up in the second half.
  • Start - Michael Mayer, Las Vegas Raiders (Ranked 24th) Michael Mayer is one of fantasy's best #2 TEs, both because of his talent and the Raiders' lack of WR depth.

MORE: Week 10 NFL power rankings Fantasy Football Week 10 Start 'Em: Running backs Must-start Week 10 RBs Kenneth Walker III, Chiefs (at ATL) Christian McCaffrey, 49ers (at DAL) Jahmyr Gibbs, Lions (vs.

MORE: Week 10 NFL picks against the spread Fantasy Football Week 10 Sit 'Em: Quarterbacks Weaker Week 10 QB plays 15.

Additional details
  • If you need TE production and don't have a consensus top-12 Week 10 fantasy tight end, here are three highly unconventional, high-upside bargains.
  • Going beyond redraft league starts and sits, "The Decider" also includes some DFS picks for different styles of games on DraftKings and FanDuel.
  • Start - Kenyon Sadiq, New York Jets (Ranked 32nd) Since busting out in Week 3, rookie Kenyon Sadiq has been largely an offensive afterthought.
  • Sit - Tucker Kraft, Green Bay Packers (Ranked 10th) Tucker Kraft was one of my suggested busts last week, and he didn't disappoint.
  • Also, if you're planning to start one of those previously referenced top-12 fantasy TEs, these three are riskier than usual.

How this summary was made: extractive summary — built from the sources' own reporting. It is drawn only from the reporting of the sources listed below — read the originals for full detail. How we summarize →

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Every article behind this summary — 2 articles from 1 outlet