The actress hosted the season finale of the late-night comedy sketch show's milestone season 50 on May 17

The daytime talk show host is a mom to daughters, Frankie and Olive

Barrymore was just 6 years old when she made the movie

In an exclusive interview with PEOPLE, the singer-songwriter also opens up about the making of her debut album 'At the Beach, In Every Life'

The talk show host, however, urges women to do what works for them

Stefani also opened up about her ideal date night with Shelton, which includes sitting on separate couches at home

Nesh Pillay told Barrymore she's "grateful" because while "I cannot retain my memories, I can make memories"

The talk show host and Adam Sandler have starred in three movies together

The celebrity chef had a candid conversation about how child stardom affects adulthood during the 'The Drew Barrymore Show' on Tuesday, April 22

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“The most valuable lesson I've learned is that nothing is a given,” the host told her ‘Drew Barrymore Show’ audience

Gisele Bündchen and Reese Witherspoon both wear the silhouette, too

"I told Wolfie, 'Make sure I'm dead,'" she recalled of a conversation with her son, shared with the late Eddie Van Halen

The daytime talk show host shares her two daughters, Olive and Frankie, with ex-husband Will Kopelman

Matt Bomer gave the daytime talk show host a steamy greeting!

"I'm like, 'I have mother issues! I'm leaving,' " the actress recalled of her reaction

The actress shares her two daughters with ex Will Kopelman

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The ‘Drew Barrymore Show’ host recalled De Niro as a “lovely and kind” costar on the 2009 film ‘Everybody’s Fine’

"It doesn't cross my mind to behave like that. Like, if you put a fishing pole in it, why are you not going to follow through?" the actress said