The 49ers said Wednesday they plan to release defensive tackle Javon Hargrave with a post-June 1 designation, but that wide receiver Deebo Samuel Sr. is not going anywhere.

49ers general manager John Lynch, coach Kyle Shanahan and quarterback Brock Purdy have made it clear that they intend to reach an agreement with the hope that it will be done sooner than later.

The 49ers removed Nick Sorensen from his role as defensive coordinator Tuesday night but hope to retain him in a different post, a source said.

49ers quarterback Brock Purdy avoided a serious injury to his right elbow but is unlikely to play Sunday against the Cardinals.

After taking a sack in Monday's game, 49ers QB Brock Purdy said his right arm felt like it was "on fire." According to coach Kyle Shanahan, the initial indication is a nerve issue unrelated to the ulnar collateral ligament Purdy tore in January 2023.

After a back-and-forth first half, the Lions settled in and took over the game in the second half.

The 49ers have many decisions to make in 2025 after missing the playoffs for the first time since 2020.

The 49ers suspended linebacker De'Vondre Campbell three games for refusing to enter Thursday night's game against the Rams.

Coach Kyle Shanahan says the 49ers are working on the best way to part with linebacker De'Vondre Campbell after he refused to enter Thursday night's game.

Niners players blasted linebacker De'Vondre Campbell after Thursday's loss to the Rams, calling his refusal to enter the game for an injured Dre Greenlaw a "selfish decision."

The Rams' playoff chances now sit as 52% and 49% to win the division entering the weekend.

Since training camp, the 49ers season hasn't gone as planned amid injuries to star players and on-field struggles.

San Francisco wide receiver Deebo Samuel on Tuesday stood by the sentiment he expressed in a since-deleted social media post in which he attributed his downturn in production to a lack of opportunities.

The TD drive lasted less than three minutes and featured multiple explosive plays to put the 49ers up 7-0.

49ers running backs Christian McCaffrey and Jordan Mason are both headed to injured reserve.

49ers RB Christian McCaffrey, playing in just his fourth game since returning from Achilles tendinitis, suffered a PCL injury Sunday night in Buffalo that coach Kyle Shanahan described as potentially season-ending.

49ers quarterback Brock Purdy is expected to return Sunday night against the Bills, but offensive tackle Trent Williams, defensive end Nick Bosa and cornerback Deommodore Lenoir have been ruled out.

49ers linebacker Fred Warner revealed for the first time Wednesday that he has been playing through a fractured bone in his ankle that he sustained in a Sept. 29 win against the Patriots.

The 49ers lost to the Packers by 28 points on Sunday, the franchise's largest margin of defeat in 74 meetings with Green Bay. Said linebacker Fred Warner: "This is probably one of the worst ones I've been a part of."

The 49ers will start Brandon Allen at quarterback against the Packers in place of an injured Brock Purdy. Defensive end Nick Bosa also will miss the game with injuries to his left hip and oblique.