Scientists Made a ‘Woolly Mouse’ in Quest to Resurrect Mammoths

Welcome back to the Abstract!
Let me start this column with a question: Are you a man or a mouse? Or a mammoth? Or a mammoth mouse? Okay, that was more than one question, but in my defense, scientists made a bunch of mammothy mice and I’m getting my taxonomical lines crossed.
Then, hornet guts: What’s in them? The answer will haunt your nightmares (but in a fun way). Next, quench your thirst with primordial supernova water. Last, a heartwarming story about how we averted death by cosmic radiation. I love that for us!
Introducing: The Woolly Mam-mouse
Chen, Rui et al. “Multiplex-edited mice recapitulate woolly mammoth hair phenotypes.” bioRxiv.
The last woolly mammoths vanished from Earth 4,000 years ago, but they loom large in our imaginations. The extinct proboscideans have become the main avatar of a push to “de-extinct” lost animals by creating genetic “proxy” species spliced together with gene-editing tools like CRISPR. Yes, this movement is very reminiscent of Jurassic Park—except the proposed attractions are dodos, thylacines, and mammoths instead of T-rexes with a specific taste for lawyers.
Now, researchers working for Colossal Biosciences, a biotech startup that bills itself as the “de-extinction company” have unveiled a “woolly mouse” chimera, according to a new preprint study. These mice have “exaggerated hair phenotypes including curly, textured coats, and golden-brown hair,” which the researchers claim could shed light into the genetic adaptations of mammoths. The mice don’t have any actual mammoth DNA in them; rather, the team toggled gene mutations that are similar to those found in mammoths, and other mammals.
“This study establishes a rapid platform for testing mammoth-centric genetic variants while advancing methods for complex genetic model generation,” said researchers led by Rui Chen of Colossal Biosciences. “These approaches inform de-extinction efforts and research into the genetic basis of mammalian hair development and cold adaptation.”
The study was published this week on bioRxiv, a server for biology preprints that are hot off the press and have not yet gone through the peer review process. The team also disclosed competing interests in this statement: “The authors have filed a patent application based on the results of this work. All authors are current or former employees, or scientific advisors/consultants for Colossal Biosciences and/or Form Bio, and may hold stock and/or stock options in these companies.”
In other words, this study has not been traditionally vetted and the authors acknowledge financial interest in the outcome, which are important considerations in evaluating its results. Some scientists have already pushed back on the team’s claim that the mice offer a meaningful step toward a resurrected mammoth.
Jurassic Park may be a good guide here not only for its literal premise of resurrecting animals, but for its excellent portrayal of how commercialization shapes our conception of scientific breakthroughs. After all, science is very cool, people are often enthused about it, and this makes it easy to market lofty and appealing narratives about its progress. John Hammond (the British dino tycoon) wants to make money off his park, sure, but he also has a grander sense of purpose that he has even sold himself on. “How can we stand in the light of discovery and not act?” he asks his guests over a meal. Hungry dinosaurs bluntly counter this techno-optimism by making meals of several characters.
Of course, it’s just a movie (albeit the best one ever made). Future mammoth proxies are unlikely to go on murderous rampages, though they would be well within their rights to do so. But it will be interesting to watch how this clear commercial interest in de-extinction will materialize in the coming years and, crucially, what popular narratives emerge from it. Are proxies possible? If so, who are they for? Can simulacra of dead things help save living things? Or is it all just a stunt? (Stunts can be very profitable, after all!)
This study demonstrates an eagerness to prove that the rubber is meeting the road in the journey to de-extinction, but nobody knows where this road leads or what Frankensteinian creatures might show up along the way. For a deeper dive into the thorny dimensions of de-extinction efforts, I recommend Sabrina Imbler’s thoughtful feature on the topic for Defector.
And while the methods and conclusions of this preprint should be adjudicated by experts, I did want to end on a light note by spotlighting the many luxurious mouse hairdos described in the study, such as “wavy pelage” and “curly vibrissae.” If nothing else, these mice chimeras can serve as inspiration for your next haircut.
There’s a Party in these Hornet Guts and Everyone’s Invited
In what is hands-down the gnarliest study of the week, scientists rummaged through hundreds of hornet guts to see what they were eating. Why would any sane person want to do such a thing? Because, like Mount Everest, the hornet guts are there. Oh, and also, the Asian hornet (Vespa velutina) is an invasive predator that is wreaking havoc across Europe, and understanding its diet is key to mitigating its ecological impact.
And boy, this hornet did not disappoint: The team found a veritable buffet of 1,449 different species in the bellies of its babies (larvae).
“Through deep sequencing of gut samples from >1500 V. velutina larvae originating from 103 nests, the aim of this study was to provide the first large-scale dietary analysis of V. velutina across European regions,” said researchers led by Siffreya Pedersen at the University of Exeter.
“We evidence V. velutina as a highly adaptable predator with an incredibly wide array of invertebrate prey, spanning the orders Hymenoptera, Diptera, Hemiptera, Coleoptera, Lepidoptera, and Araneae with considerable dietary species variation across seasons and geographical regions,” the team said.

Mitigating the devastating impacts of this predator will clearly be a tough job, as it can apparently subsist on any biofuel it can catch. The Asian hornet is particularly fond of devouring pollinators like the honey bee Apis mellifera, and it is truly chilling to read about their tactics.
“The hornets hunt A. mellifera by ‘hawking’ outside of hive entrances and intercepting returning workers, or by targeting individual foragers at floral patches,” the team said. “Unlike the Eastern honey bee, Apis cerana, which has evolved defensive mechanisms such as killing the hornets through thermal shock (bee balling), A. mellifera has no effective defence against V. velutina.”
Insect studies will just casually mention insane defense moves like “bee balling” that sound like Bioshock plasmids. All in all, the Asian hornet’s gastronomical versatility distinguishes it as “a potential ecosystem-level pressure” in Europe and a threat that must be addressed. But even as we vow to curb its carnage, we must salute this epicurious gourmand.
A Glimpse of the Cosmic Wellspring
Whalen, D.J. et al. “Abundant water from primordial supernovae at cosmic dawn.” Nature Astronomy.
We now move from the gnarly to the serene. The very title of this study is a slice of zen: “Abundant water from primordial supernovae at cosmic dawn.” Forget “abracadabra” and other incantations. This is the kind of phrase I believe might make you levitate into enlightened transcendence if you repeat it enough.
Water is the essential catalyst for life as we know it on Earth, and it is the fundamental parameter that we use to assess the habitability of other worlds. For this reason, the origins of water in the universe is a major research area that can shed light on the odds that life has emerged elsewhere in space and time.
Researchers have now simulated the explosions of the first very stars in the universe, known as population III, which were much more massive and chemically homogenous than their stellar descendants. The models predicted that water formed in the cooling haloes that surrounded these inaugural supernovae, hinting that this vital compound has been around for about 13.6 billion years.
“Primordial (or population III) supernovae were the first nucleosynthetic engines in the Universe, and they forged the heavy elements required for the later formation of planets and life,” said researchers led by D.J. Whalen of the University of Portsmouth. “Here we present numerical simulations that show that the first water in the Universe formed in population III…supernovae.”
“The primary sites of water production in these remnants are dense molecular cloud cores, which in some cases were enriched with primordial water to mass fractions that were only a factor of a few below those in the Solar System today,” the team said. “Besides revealing that a primary ingredient for life was already in place in the Universe 100–200 [million years] after the Big Bang, our simulations show that water was probably a key constituent of the first galaxies.”
Water, water everywhere? More like water, water, every-when. Water has been around almost as long as starlight, which makes it obvious that there are lots of aliens out there who must be just actively ignoring us.
An Update on the Ozone Layer: Earth’s Bullet-Proof Vest
Wang, Peidong et al. “Fingerprinting the recovery of Antarctic ozone.” Nature.
We’ll close on a high note—so high, in fact, that it is located in the stratosphere. If you are an ancient crone like me, you might recall a time called the 1980s when humans realized that many commercial chemicals, especially chlorofluorocarbons (CFCs), were eating away at an atmospheric layer of ozone gas that helpfully protects life on Earth from deadly radiation. People were like, “I don’t want to be exposed to deadly radiation!” so they banned ozone-depleting substances (ODSs) in the Montreal Protocol of 1987.
The Montreal Protocol has often been held up as one of the biggest environmental successes in history, and a study out this week has further bolstered its reputation. While a lot of research has shown evidence of healing ozone, scientists have now adapted advanced climate change tools to check in on the famous ozone “hole” that once gaped over Antarctica.
“We performed a pattern-based fingerprint analysis for Antarctic ozone recovery, analogous to fingerprinting anthropogenic climate change,” said researchers led by Peidong Wang at the Massachusetts Institute of Technology. “We demonstrate that the data and simulations show compelling agreement in the fingerprint pattern of the ozone response to decreasing ODSs since 2005.”
“Our results provide robust statistical and physical evidence that actions taken under the Montreal Protocol to reduce ODSs are indeed resulting in the beginning of Antarctic ozone recovery,” the team said.
Boom! Take the win, humanity, we need all the morale we can get. Indeed, the Montreal Protocol is often cited as an aspirational model of the international collaboration required to combat climate change. This is a bit of an oversimplification—the entire global economy was not built on CFCs, and fossil fuels are a much harder habit to kick. Still, if you’re a person who doesn’t like being bombarded with carcinogenic space particles, rejoice. And if you do like radiation exposure, I have some waterfront property on Mars to sell you.
Thanks for reading! See you next week.